منابع مشابه
Managing resistance to anti-HIV drugs: an important consideration for effective disease management.
Current recommendations for the treatment of HIV-infected patients advise highly active antiretroviral therapy (HAART) consisting of combinations of 3 or more drugs to provide long-term clinical benefit. This is because only a complete suppression of virus replication will be able to prevent virus drug resistance, the main cause of drug failure. Virus drug resistance may remain a cause of conce...
متن کاملHIV therapy: managing resistance.
O the last years, a number of potent drugs have been developed that inhibit HIV-1 replication in vivo. Treatment regimes involving a combination of three or more different drugs can induce a decline in virus load by several orders of magnitude, as well as a significant rise in the CD4 cell count. The drugs currently in use mainly fall into two classes: reverse transcriptase inhibitors prevent i...
متن کاملReactive resistance to anti-angiogenic drugs
most types of cancers, and particularly in metastatic renal cell carcinoma, with several drugs currently approved for daily clinical practice. However, secondary resistance to this family of drugs is constantly observed, and the mechanisms of resistance remain poorly understood in patients. Recently, we demonstrated that sunitinib, a tyrosine kinase inhibitor, was able to generate resistance to...
متن کاملTiming the Emergence of Resistance to Anti-HIV Drugs with Large Genetic Barriers
New antiretroviral drugs that offer large genetic barriers to resistance, such as the recently approved inhibitors of HIV-1 protease, tipranavir and darunavir, present promising weapons to avert the failure of current therapies for HIV infection. Optimal treatment strategies with the new drugs, however, are yet to be established. A key limitation is the poor understanding of the process by whic...
متن کاملPrimary drug resistance to anti-tuberculous drugs in Karachi.
OBJECTIVE To assess the frequency of primary drug resistance among newly diagnosed tuberculosis cases in Karachi. STUDY DESIGN Cross-sectional study. PLACE AND DURATION OF STUDY Multicentric study involving various TB clinics and treatment centres of Karachi between April to December 2005. METHODOLOGY The frequency of drug resistance among new TB patients was evaluated using a non-probabi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drugs
سال: 1999
ISSN: 0012-6667
DOI: 10.2165/00003495-199957030-00006